Friday, October 9, 2009

Avance Sempre Na vida as coisas, às vezes, andam muito devagar.
Mas é importante não parar.
Mesmo um pequeno avanço na direção certa já é um progresso, e qualquer um pode fazer um pequeno progresso.Se você não conseguir fazer uma coisa grandiosa hoje, faça alguma coisa pequena.
Pequenos riachos acabam convertendo-se em grandes rios.
Continue andando e fazendo.
O que parecia fora de alcance esta manhã vai parecer um pouco mais próximo amanhã ao anoitecer se você continuar movendo-se para frente.
A cada momento intenso e apaixonado que você dedica a seu objetivo, um pouquinho mais você se aproxima dele.Se você pára completamente é muito mais difícil começar tudo de novo.Então continue andando e fazendo.
Não desperdice a base que você já construiu.
Existe alguma coisa que você pode fazer agora mesmo, hoje, neste exato instante.Pode não ser muito mas vai mantê-lo no jogo.
Vá rápido quando puder.
Vá devagar quando for obrigado.
Mas, seja, lá o que for, continue.
O importante é não parar!!!
Autor desconhecido.

Este poema veio do Cantinho da Ritinha, lá do cantinho do mundo das mulheres.
Valeu Amiga.

DESEJO A TODOS UM LINDO FINAL DE SEMANA.
VOU VIAJAR PARA CASA DOS MEUS PAIS, HOJE A NOITE.
DEIXO UM CARINHO E ABRAÇO BEM FORTE A TODOS.
QUANDO VOLTAR RESPONDEREI TODOS OS CARINHOS DE VOCÊS.

FIQUEM COM DEUS, MEUS AMIGOS.
TENHAM UM LINDO FERIADÃO.


VENHA COMEMORAR COM ESTES DOIS BLOGS.
LEVE SEU SELINHO DE 5.000MIL VISITAS.


Poetas-Um Vôo Livre

Sinal de Liberdade-uma expressão de sentimento

Thursday, October 8, 2009

A ESPERANÇA.


http://www.umemcristo.blogger.com.br/esperanca-blogger.jpg

HOJE COMPREI UM LIVRO QUE FALA DA ESPERANÇA.

E É DELA QUE PRECISAMOS, PARA VENCER E
CONTINUARMOS A NOSSA LUTA.

TER ESPERANÇA É TER A FÉ SEMPRE MUITO VIVA DENTRO DE NÓS.
É TER A CORAGEM DE LUTAR E VENCER TODOS OS OBSTÁCULOS.
É ACREDITAR QUE TUDO É POSSÍVEL, E QUE NADA É O FIM...
AS VEZES O SOFRIMENTO, É O NOSSO AMADURECIMENTO,
PARA A VIDA.

TEMOS QUE SERMOS FORTES E ACEITAR ALGUNS DESSES DESAFIOS,
QUE NOS SÃO PROPOSTOS.
SEI QUE, PASSEI POR ALGUNS MOMENTOS, DOLOROSOS DE ACEITAÇÃO.
MAS NÃO PODEMOS FUGIR DELES.
ELES EXISTEM E ESTÃO AI PARA SEREM ENCARADOS E ENFRENTADOS.
A ESPERANÇA É A NOSSA FORÇA ESPERITUAL, QUE TEMOS PARA VIVER.
É A NOSSA MOLA PROPULSORA, DO DIA A DIA.
E ESTAMOS AI. PARA CONTINUAR E LUTAR...
SEM PENSAR EM DESISTIR.
A VIDA NÃO PODE SER DESISTIDA.
TEM QUE SER SIM, ASSISTIDA COMO SENDO UM GRANDE ESPECTÁCULO.
O MAIOR E MAIS BELO DE TODOS.
VIVA A VIDA...VIVA A ESPERANÇA.

(AUTORIA: SANDRA ANDRADE).


VENHA COMEMORAR COM ESTES DOIS BLOGS.
LEVE SEU SELINHO DE 5.000MIL VISITAS.


Poetas-Um Vôo Livre

Sinal de Liberdade-uma expressão de sentimento

A Vaccine For White Line Fever?

A study claims that it's possible to immunize against cocaine: Cocaine Vaccine for the Treatment of Cocaine Dependence in Methadone-Maintained Patients. But does it work? And will it be useful?
The idea of an anti-drug vaccine is not new; as DrugMonkey explains in his post on this paper, monkeys were being given experimental anti-morphine vaccines as long ago as the 1970s. This one has been under development for years, but this is the first randomized controlled trial to investigate whether it helps addicts to use less of the drug.

Martell et al, a Yale-based group, recruited 115 patients. They all used both cocaine and opiates, and were given methadone treatment to try to reduce their opiate use. The reason why the authors chose to focus on these patients is that the methadone keeps people coming back for more and makes them less likely to drop out of the study, or as they put it, "retention in methadone maintenance programs is substantially better than in primary cocaine treatment programs. We also offered subjects $15 per week to enhance retention."

The vaccine consists of a bacterial protein (cholera toxin B-subunit) chemically linked to a cocaine-like molecule, succinylnorcocaine. Like all vaccines, it works by provoking an immune response. The bacterial protein triggers the production of antibodies, proteins which recognize and bind to specific targets.

In this case, the antibodies bind cocaine (anti-cocaine IgG) because of the succinylnorcocaine in the vaccine. Once a molecule of cocaine is bound to the antibody, it's effectively out of commission, as it cannot enter the brain. So, the vaccine should reduce or abolish the effects of the drug. The control group were given a dummy placebo vaccine.

The results? Biologically speaking, the vaccine worked, but in some people more than others. Out of the 55 subjects who were given the active vaccine, all but one produced anti-cocaine IgG. However, the amount of antibodies produced varied widely. Also, the response was short-lived. The vaccine was given 5 times over the first 12 weeks, but antibody levels did not peak until week 16, after which they fell rapidly.
And the key question - did it reduce cocaine use? Well, sort of. The authors measured drug use in terms of the proportion of urine samples which were cocaine-free. In the active vaccine group, the proportion of drug-free urine samples was higher over weeks 9 to 16, when the antibody levels were high, and this was statistically significant (treatment x time interaction: Z=2.4, P=.01). As expected, the benefit was greater in the people who made lots of antibodies (43 μg/mL) (treatment x time interaction: Z=4.8, P less than .001). But the effect was pretty small:

The bottom line was about 10% more urine samples testing negative, and even that was only true in the minority (38%) of people who responded well to the vaccine! Not very impressive, but on the other hand, the number of drug-free urine tests is a very crude measure of cocaine use. It doesn't tell us how much coke the patients used at a time, or how many times they used it per day.

Also, bear in mind that if it works, this vaccine might increase cocaine use in some people, at least at first. By binding and inactivating some of the cocaine in the bloodstream, the vaccine would mean you'd need to take more of the drug in order to feel the effects. It's curious that the authors relied on just one crude outcome measure and didn't ask the patients to describe the effects in more detail.

So, these are some interesting results, but the vaccine clearly needs a lot of work before it becomes clinically useful, as the authors admit - "Attaining high (43 μg/mL) IgG anticocaine antibody levels was associated with significantly reduced cocaine use, but only 38% of the vaccinated subjects attained these IgG levels and they had only 2 months of adequate cocaine blockade. Thus, we need improved vaccines and boosters." Quite an admission given that this study was partially funded by Celtic Pharmaceuticals, who make the vaccine.

It's also questionable whether any vaccine will be truly beneficial in treating cocaine addiction. Such a vaccine would be a way of reducing the temptation to use cocaine. In this sense, it would be just like naltrexone for heroin addicts, which blocks the effects of the drug. Or disulifram (Antabuse) for alcoholics, which makes drinking alcohol cause horrible side effects. Essentially, these treatments are ways of artificially boosting your "self-control", and they work.

But we've had naltrexone and disulifram for many years. They're cheap and safe. But we still have heroin addicts and alcoholics. This is not to say that they're never helpful - some people find them very useful. But they haven't eradicated addiction because addiction is not something that can be cured with a pill or an injection.

Addiction is a pattern of behaviour, and medications might help people to break free of it, but the causes of addiction are social, economic and psychological as well as biological. People turn to drugs and alcohol when there's nowhere else to turn, and unfortunately, there's no vaccine against that.

ResearchBlogging.orgMartell BA, Orson FM, Poling J, Mitchell E, Rossen RD, Gardner T, & Kosten TR (2009). Cocaine vaccine for the treatment of cocaine dependence in methadone-maintained patients: a randomized, double-blind, placebo-controlled efficacy trial. Archives of general psychiatry, 66 (10), 1116-23 PMID: 19805702

A Vaccine For White Line Fever?

A study claims that it's possible to immunize against cocaine: Cocaine Vaccine for the Treatment of Cocaine Dependence in Methadone-Maintained Patients. But does it work? And will it be useful?
The idea of an anti-drug vaccine is not new; as DrugMonkey explains in his post on this paper, monkeys were being given experimental anti-morphine vaccines as long ago as the 1970s. This one has been under development for years, but this is the first randomized controlled trial to investigate whether it helps addicts to use less of the drug.

Martell et al, a Yale-based group, recruited 115 patients. They all used both cocaine and opiates, and were given methadone treatment to try to reduce their opiate use. The reason why the authors chose to focus on these patients is that the methadone keeps people coming back for more and makes them less likely to drop out of the study, or as they put it, "retention in methadone maintenance programs is substantially better than in primary cocaine treatment programs. We also offered subjects $15 per week to enhance retention."

The vaccine consists of a bacterial protein (cholera toxin B-subunit) chemically linked to a cocaine-like molecule, succinylnorcocaine. Like all vaccines, it works by provoking an immune response. The bacterial protein triggers the production of antibodies, proteins which recognize and bind to specific targets.

In this case, the antibodies bind cocaine (anti-cocaine IgG) because of the succinylnorcocaine in the vaccine. Once a molecule of cocaine is bound to the antibody, it's effectively out of commission, as it cannot enter the brain. So, the vaccine should reduce or abolish the effects of the drug. The control group were given a dummy placebo vaccine.

The results? Biologically speaking, the vaccine worked, but in some people more than others. Out of the 55 subjects who were given the active vaccine, all but one produced anti-cocaine IgG. However, the amount of antibodies produced varied widely. Also, the response was short-lived. The vaccine was given 5 times over the first 12 weeks, but antibody levels did not peak until week 16, after which they fell rapidly.
And the key question - did it reduce cocaine use? Well, sort of. The authors measured drug use in terms of the proportion of urine samples which were cocaine-free. In the active vaccine group, the proportion of drug-free urine samples was higher over weeks 9 to 16, when the antibody levels were high, and this was statistically significant (treatment x time interaction: Z=2.4, P=.01). As expected, the benefit was greater in the people who made lots of antibodies (43 μg/mL) (treatment x time interaction: Z=4.8, P less than .001). But the effect was pretty small:

The bottom line was about 10% more urine samples testing negative, and even that was only true in the minority (38%) of people who responded well to the vaccine! Not very impressive, but on the other hand, the number of drug-free urine tests is a very crude measure of cocaine use. It doesn't tell us how much coke the patients used at a time, or how many times they used it per day.

Also, bear in mind that if it works, this vaccine might increase cocaine use in some people, at least at first. By binding and inactivating some of the cocaine in the bloodstream, the vaccine would mean you'd need to take more of the drug in order to feel the effects. It's curious that the authors relied on just one crude outcome measure and didn't ask the patients to describe the effects in more detail.

So, these are some interesting results, but the vaccine clearly needs a lot of work before it becomes clinically useful, as the authors admit - "Attaining high (43 μg/mL) IgG anticocaine antibody levels was associated with significantly reduced cocaine use, but only 38% of the vaccinated subjects attained these IgG levels and they had only 2 months of adequate cocaine blockade. Thus, we need improved vaccines and boosters." Quite an admission given that this study was partially funded by Celtic Pharmaceuticals, who make the vaccine.

It's also questionable whether any vaccine will be truly beneficial in treating cocaine addiction. Such a vaccine would be a way of reducing the temptation to use cocaine. In this sense, it would be just like naltrexone for heroin addicts, which blocks the effects of the drug. Or disulifram (Antabuse) for alcoholics, which makes drinking alcohol cause horrible side effects. Essentially, these treatments are ways of artificially boosting your "self-control", and they work.

But we've had naltrexone and disulifram for many years. They're cheap and safe. But we still have heroin addicts and alcoholics. This is not to say that they're never helpful - some people find them very useful. But they haven't eradicated addiction because addiction is not something that can be cured with a pill or an injection.

Addiction is a pattern of behaviour, and medications might help people to break free of it, but the causes of addiction are social, economic and psychological as well as biological. People turn to drugs and alcohol when there's nowhere else to turn, and unfortunately, there's no vaccine against that.

ResearchBlogging.orgMartell BA, Orson FM, Poling J, Mitchell E, Rossen RD, Gardner T, & Kosten TR (2009). Cocaine vaccine for the treatment of cocaine dependence in methadone-maintained patients: a randomized, double-blind, placebo-controlled efficacy trial. Archives of general psychiatry, 66 (10), 1116-23 PMID: 19805702

Wednesday, October 7, 2009

UM PRESENTE MUITO ESPECIAL DA MINHA LINDA ISA.

AGRADEÇO VOCÊ ISA PELOS LINDOS PRESENTES.


ANDO UM TANTO TRISTE, MUITAS COISAS ACONTECENDO AO MESMO TEMPO.
MAS NÃO VOU PERDER A FÉ.
EU QUE TRANSMITO A CADA UM DE VOCÊS, AGORA TAMBÉM TEREI QUE SER FORTE.
MUITAS COISAS ACABAM ACONTECENDO PARA QUE POSSAMOS TAMBÉM CRER MAIS E REPENSAR A NOSSA VIDA.


MUITO OBRIGADA A VOCÊ ISA. MEUS LINDO SONHO DE PESSOA.AMEI TODOS OS PRESENTES.


Para os meus Amigos de " Um Farol Chamado Amizade"

Com a ternura da isa.

Que esteja bem guardada... Curiosa

Flor-4778

Sandra, que Deus guie a mão do médico que te vai operar.
Rezarei por ti. Beijo.
isa

APESAR DE TUDO O QUE ESTÁ ACONTECENDO, AGORA TENHO QUE REFAZER PELA TERCEIRA VEZ A MINHA CIRURGIA.

Um mimo da isa para a Sandra.

Flor-5934

Beijo.isa.

VOU DEIXAR UM CORAÇÃO DE ROSAS PARA CADA UM DE VOCÊS QUE PASSAM POR AQUI.
ROSAS PERFUMADAS PARA TE AGRADECER O CARINHO E AFETO TÃO CONFORTANTE.
UM BEIJO A TODOS.



Tuesday, October 6, 2009

MEUS AMIGOS

Flor-4878


OLA MEUS AMIGOS!!!!
AINDA ESTOU TRISTE. NÃO CONSIGO LEMBRAR QUE PERDI TODOS OS MEUS ARQUIVOS.
SEI QUE O CARINHO DE VOCÊS, ESTÃO ME AJUDANDO MUITO.
MAS ESTOU PRECISANDO, DESSE TEMPO.
FORAM TANTOS MOMENTOS DE DEDICAÇÃO, PESQUISA E DE REPENTE...TUDO FOI PELOS ARES..
NADA QUE UM BOM RECOMEÇO E MELHOR.
UM GRANDE ABRAÇO.
ASSIM QUE PUDER VOU ESTAR VISITANDO A TODOS.
ESTÃO TODOS GUARDADOS NO MEU CORAÇÃO.




Beijos-2506

DEIXEI UM ABRAÇO PARA VOCÊM EM MEUS MIMOS.
PASSE LÁ.
Meus Mimos!

Monday, October 5, 2009

Is Freud Back in Fashion? No.

Freudian psychoanalysis is the key to treating depression, especially the post-natal kind (depression after childbirth). That's according to a Guardian article by popular British psychologist and author Oliver James. He says that recent research has proven Freud right about the mind, and that psychoanalysis works better than other treatments, like cognitive-behavioural therapy (CBT).

Neuroskeptic readers have encountered James before. He's the person who thinks that Britain is the most mentally-ill country in Europe. I disagree, but that's at least a debatable point. This time around, James's claims are just plain wrong.

So, some corrections. We've got a lot to cover, so I'll keep it brief:

"10% [of new mothers] develop a full-blown depression...which therapy should you opt for? [antidepressants] rule out breastfeeding" - No, they don't. Breast-feeding mothers are able to use antidepressants when necessary, according to the British medical guidelines and others:
Limited data on effects of SSRI exposure via breast milk on weight gain and infant development are encouraging. If a woman has been successfully treated with a SSRI in pregnancy and needs to continue therapy after delivery, there is no need to change the drug, provided the infant is full term, healthy and can be adequately monitored...
James's statement is a dangerous mistake, which could lead to new mothers worrying unduly, or even stopping their medication.

"People given chalk pills but told they are antidepressants are almost as likely to claim to feel better as people given the real thing."
- This is true in many cases, although it's a little bit more complicated than that, but this refers to trials on general adult clinical depression, not post-natal depression, which might be completely different.

There's actually only one trial comparing an antidepressant to chalk placebo pills in post-natal depression. The antidepressant, Prozac, worked remarkably well, much better than in most general adult trials. This was a small study, and we really need more research, but it's encouraging.

"Regarding the talking therapies, in one study depressed new mothers were randomly assigned to eight sessions of CBT, counselling, or to psychodynamic psychotherapy. Eighteen weeks later, the ones given dynamic therapy were most likely to have recovered (71%, versus 57% for CBT, 54% counselling)."

This is cherry-picking. In the trial in question the dynamic (psychoanalytic) therapy was slightly better than the other two when depression was assessed in one way, which is what James quotes. The difference was not statistically significant. And using another depression measurement scale, it was no better at all. Take a look, it's hardly impressive:

Plus, after 18 weeks, none of the three psychotherapies was any better to the control, which consisted of doing precisely nothing at all.

"Studies done in the last 15 years have largely confirmed Freud's basic theories. Dreams have been proven to contain meaning." - Nope. Freud believed that dreams exist to fulfil our fantasies, often although not always sexual ones. We dream about what we'd like to do. Except we don't actually dream about it, because we'd find much of it shameful, so our minds hide the true meaning behind layers of metaphor and so forth. "Steep inclines, ladders and stairs, and going up or down them, are symbolic representations of the sexual act..."

If you believe that, good for you, and some people still do, but there has been no research over the past 15 years supporting this (although this is quite interesting). There was never any research really, just anecdotes

"Early childhood experience has been shown to be a major determinant of adult character." Nope. The big story over the past decade is that contra Freud, "shared environment", i.e. family life and child rearing make almost no contribution to adult personality, which is determined by a combination of genes and "individual environment" unrelated to family background. One could argue about the merits of this research but to say that modern psychology is moving towards a Freudian view is absurd. The opposite is true.

"And it is now accepted by almost all psychologists that we do have an unconscious and that it can contain material that has been repressed because it is unacceptable to the conscious mind." Nope. Some psychologists do still believe in "repressed memory" theory, but it's highly controversial. Many consider it a dangerous myth associated with "recovered memory therapy" which has led to false accusations of sexual abuse, Satanic rituals, etc. Again, they may be wrong, but to assert that "almost all" psychologists accept it is bizarre.

"Although slow to be tested, the clinical technique [of Freudian psychoanalysis] has now also been demonstrated to work. The strongest evidence for its superiority over cognitive, short-term treatments was published last year..."

First off, the trial referred to was not about post-natal depression, and it didn't test cognitive therapy at all. It compared long-term psychodynamic therapy, vs. short-term psychodynamic therapy, vs. "solution-focused therapy" in the treatment of various chronic emotional problems. No CBT was harmed in the making of this study.

After 1 year, long-term dynamic therapy was the worst of the three. At 2 years, they were the same. At 3 years, long-term dynamic therapy was the best. Although all these differences were small. Short-term dynamic therapy was no better than solution-focused therapy, which is rather a point against psychoanalysis since solution-focused therapy is firmly non-Freudian. And amusingly, the "short-term" dynamic therapy was actually twice as long as the dynamic therapy in the first study discussed above, which James praised! (20 weekly sessions vs 10). (Edit 23.10.09)

*

James ends by slagging off CBT and its practitioners, and suggesting that we need a "Campaign for Real Therapy", i.e. not CBT, something he has suggested before. This is the key to understanding why James wrote his muddled piece.

The British government is currently pouring hundreds of millions into the IAPT campaign which aims to "implement National Institute for Health and Clinical Excellence (NICE) guidelines for people suffering from depression and anxiety disorders". NICE guidelines essentially only recommend CBT, so this is effectively a campaign to massively expand CBT services. CBT is widely seen as the only psychotherapy which has been proven to work, in Britain and increasingly elsewhere too.

Oliver James, like quite a lot of people, doesn't like this. And in that, he has a point. There are serious debates to be had over whether CBT is really better than other therapies, and whether we really need lots more of it. There are also serious debates to be had over whether antidepressants are really effective and whether they are over-used. But these are all extremely complex questions. There are no easy answers, no short cuts, no panaceas, and James's brand of sectarian polemic is exactly what we don't need.

[BPSDB]