Friday, June 4, 2010

Vicodin And Lower Blood Pressuee

backward "Bicentennial Celebration, May 25" Missing in Action

A year of "Knight" to celebrate this May 25, day of the bicentennial of our country.
very nervous and anxious, but happy you got your outfit, your black hat and your new shoes to match. You were beautiful!, But what made me happiest was to see you so happy and so excited about what would happen while later ..
As you get dressed (this year without having to negotiate with candy or cookies let you change it wonderfully well) with your sweet little voice told me, "Mom, sir!". You were so happy to perform, to share with your colleagues, you had the night before when you tried your hat, a smile from ear to ear. We
Garden and your breast and your teacher inclusive love died when you were so smart, jiji!, you were a gentleman of the period.
recommendation of them and my family, including your father, I decided to see hidden behind the doorframe, and eavesdrop to see you immediately. This was because last year (see entry) he acts for the July 9 and went out on stage and saw me standing in the background, you began to mourn and ran into my arms, there was no way you could convince that person to return with friends to complete the act, we wept and all the photos came out with a pot to the ground, lol!. You had tested more than good for that act, even your integrator then (Leti) had been outside, because you integrate, participate and you can deal with each test a fantastic, like the rest of your classmates. But your mastitis that day broke down and your participation lasted two seconds.
So providing your possible reaction we decided to make that decision, I would be in secret, lest they see me, Dad would film and your godmother would take the photos.
was beautiful!, You came on stage riding a horse with a cart (the horse made with a broom handle and the cart of cardboard), greet the audience, gave a turn and get out. Such was the emotion I felt, that hidden and everything, I could not help being moved while your godmother would say, "Do not cry, do not cry you're gonna make me mourn me." I saw so great, so nice, it was impossible not long mom a tear, so long a few, jajaj!. I was so happy, so proud of you my King ...
After that came a "core" with umbrellas, which were decorated with blue and white ribbons. Mom made the best he could yours, it is not very good at crafts, but with love, everything is fixable. To dance with the umbrella in hand needs the help of Lucia, and with your support, was gorgeous.
When it was over we went with dad to meet you, fill you with kisses and told you how proud we were of you.
As I told you Tata (grandfather) and Titi (your aunt, you shall be called), who did not want to lose your performance and went to see you, thrashing with both eyes looking for me everywhere, but you stayed calm and a smile. At one point, near the end, our eyes met and I saw the bottom half hidden, but you kept dancing with your friends without any problems ... You're growing, you're more mature, though we stuck all the time, both learned to let go a little hand, and that's wonderful, because it is part of life, your growth and my growth as a mom. Silvi
thy bosom came to congratulate you, like Lucia and both said how beautiful you've been.
That pride you feel this morning Valen! ... I think I used the word "pride" many times in this post, but there is no other way to describe what we feel when we see you there.
Thank you for life so happy, make us happy every day with these little things, which for us are immense.

We love you son!


Here are some pics, I released an album on facebook, so many of you probably saw them, so for those who did not see here are some photos of this beautiful day.


The world's most beautiful smile! ... Trying on the hat last night.


My handsome knight, ready to act. At home before going to the garden


Healthy the photo as a gentleman


With Lucy, my teacher integration. It shows the affection that you have not it, lol!


onstage riding a horse ... the godmother of emotion took the picture for either side, lol!


round dance with my friends.


Korea umbrella, with the help of Lu came out really cute!


With Silvi, my teacher.


Kiss my dad was happy and proud of my performance.


Ceci With my godmother did not lose my spot.


With "Titi" (my aunt) and my "Tata" (abu mother)


With directors of the garden, Charles and Nati, who love Valen.



Thursday, June 3, 2010

UMA HISTÓRIA DE AMOR!!

HISTÓRIA DE AMOR!

A moça desta foto se chama Katie Kirkpatrick, e tem 21 anos. Ao lado dela está seu noivo Nick de 23 anos..
A foto foi tirada pouco antes da cerimônia de casamento dos dois, realizada em 11 de janeiro de 2005, nos EUA. Katie tem câncer em estado terminal e passa horas por dia recebendo medicação.
Na foto Nick aguarda o término de mais uma de suas sessões.



Apesar de sentir muita dor, de vários órgãos esteram apresentando falências e de ter que recorrer à morfina, Katie levou adiante o casamento e fez questão de cuidar de todos os detalhes.

O vestido teve que ser ajustado várias vezes, pois Katie perde peso todos os dias devido ao câncer.



Um acessório inusitado na festa foi o tubo de oxigênio usado por Katie. Ele acompanhou a noiva em toda a cerimônia e na festa também.

O outro casal da foto são os pais de Nick, emocionados com o casamento do filho com a mulher que ele foi namorado desde a adolescência.



Katie, sentada em uma cadeira de rodas e com o tubo de oxigênio, escutando o marido e os amigos cantando para ela.



No meio da festa, Katie pára para descansar um pouco. A dor a impede de ficar em pé por muito tempo.



Katie morreu 5 dias depois do casamento. Ver uma mulher tão debilitada vestida de noiva e com um sorriso nos lábios nos faz pensar...a felicidade sempre está ao alcance, dure enquanto dure, por isso devemos deixar de complicar nossas vidas...

A vida é curta, por isso


Trabalhe como se fosse seu primeiro dia

perdoe rapidamente
beije demoradamente, ame verdadeiramente
ría incontrolavelmente
e nunca deixe de sorrir
por mas estranho que seja o motivo.
A vida pode não ser a festa que esperamos
mas enquanto estamos aqui, devemos sorrir e agradecer...



VELA DO CÂNCER
ORE POR TODOS OS QUE PADECEM DESSE TERRÍVEL MAL E FAÇA CIRCULAR ESTA VELA
.
SEJA UMA PESSOA A MAIS NESSE CÍRCULO DE ORAÇÃO.






Uma vela não perde nada ao acender outra. Por favor, mantenha esta vela circulando e estará ajudando muitas pessoasl

ASSIM COMO ESTA HISTÓRIA, QUE ACONTECEU NOS ESTADOS UNIDOS, AQUI PERTINHO DE JARAGUÁ DO SUL, TAMBÉM ACONTECEU UM EXEMPLO DESSES. A MOÇA COM 24 ANOS MORREU UMA SEMANA DEPOIS QUE SE CASOU.. SEU SONHO ERA DE NÃO MORRER SOLTEIRA.
O CASAMENTO FOI REALIZADO E LOGO ELA FALECEU.
A VIDA É FEITA DESSES MOMENTOS...
E DE TANTOS OUTROS.... E AS VEZES TEMOS QUE ACEITAR AS NOSSAS DIFÍCEIS RESIGNAÇÕES...E DESAFIOS DE SOBREVIVÊNCIA...

SELO EXCLUSIVO DO BLOG

TEM UM GRANDE ABRAÇO PARA VOCÊ!!!

Wednesday, June 2, 2010

Serial Killers

Much of Britain is currently following the trial of Steven Griffiths, or as he'd like you to refer to him, the Crossbow Cannibal.

Serial killers are always newsworthy, and Griffiths has killed at least three women in cold blood. (He did use a crossbow, but I think the newspapers made up the cannibalism.) But it's Griffiths's interests that have really got people's attention.

It turns out that before he became a serial killer, he was a man obsessed with... serial killers. His Amazon wish list was full of books about murder. He has a degree in psychology, and he was working on his PhD, in Criminology. Guess what his research was about.

Griffiths is therefore a kind of real life Hannibal Lecter or Dexter, an expert in murderers who is himself one. He's also a good example of the fact that, unlike on TV, real life serial killers are never cool and sophisticated, nor even charmingly eccentric, just weird and pathetic. Not to mention lazy, given that he was still working on his PhD after 6 years...

Yet there is an interesting question: was Griffiths a good criminologist? Does he have a unique insight into serial killers? We'll probably never know, at least not until (or if) the police release some of his writings. But it seems to me that he might have done.

When the average person hears about the crimes of someone like Griffiths, we are not just shocked but confused - it seems incomprehensible. I can understand why someone would want to rob me for my wallet, because I like money too. I can understand how one guy might kill another in a drunken fight, because I've been drunk too. Of course this doesn't mean I condone either crime, but they don't leave me scratching my head; I can see how it happens.

I cannot begin to understand why Griffiths did what he did. My understanding of humanity doesn't cover him. But he is human, so all that really means is that my understanding is limited. Someone understands people like Griffiths, it can't be impossible; but it may be that the only way to understand a serial killer is to be one.

The same may be true of less dramatic mental disorders. Karl Jaspers believed that the hallmark of severe mental illness is symptoms that are impossible to understand: they just exist. I've experienced depression; I've also read an awful lot about it and published academic papers on it. My own illness taught me much more about depression than my reading. Maybe I've been reading the wrong things. I don't think so.

Serial Killers

Much of Britain is currently following the trial of Steven Griffiths, or as he'd like you to refer to him, the Crossbow Cannibal.

Serial killers are always newsworthy, and Griffiths has killed at least three women in cold blood. (He did use a crossbow, but I think the newspapers made up the cannibalism.) But it's Griffiths's interests that have really got people's attention.

It turns out that before he became a serial killer, he was a man obsessed with... serial killers. His Amazon wish list was full of books about murder. He has a degree in psychology, and he was working on his PhD, in Criminology. Guess what his research was about.

Griffiths is therefore a kind of real life Hannibal Lecter or Dexter, an expert in murderers who is himself one. He's also a good example of the fact that, unlike on TV, real life serial killers are never cool and sophisticated, nor even charmingly eccentric, just weird and pathetic. Not to mention lazy, given that he was still working on his PhD after 6 years...

Yet there is an interesting question: was Griffiths a good criminologist? Does he have a unique insight into serial killers? We'll probably never know, at least not until (or if) the police release some of his writings. But it seems to me that he might have done.

When the average person hears about the crimes of someone like Griffiths, we are not just shocked but confused - it seems incomprehensible. I can understand why someone would want to rob me for my wallet, because I like money too. I can understand how one guy might kill another in a drunken fight, because I've been drunk too. Of course this doesn't mean I condone either crime, but they don't leave me scratching my head; I can see how it happens.

I cannot begin to understand why Griffiths did what he did. My understanding of humanity doesn't cover him. But he is human, so all that really means is that my understanding is limited. Someone understands people like Griffiths, it can't be impossible; but it may be that the only way to understand a serial killer is to be one.

The same may be true of less dramatic mental disorders. Karl Jaspers believed that the hallmark of severe mental illness is symptoms that are impossible to understand: they just exist. I've experienced depression; I've also read an awful lot about it and published academic papers on it. My own illness taught me much more about depression than my reading. Maybe I've been reading the wrong things. I don't think so.

24 Hour Laundromat Chinese

Felicidades Lucas Basquiat

Lucas reaches age 8 at his home in Valencia and he and his feline brother Nino.


A lack of recent photographs, including video of Luke from his YouTube channel.




To learn more about Lucas and family visit:
http://www.fotolog.com/misgatos/
http://www.flickr .com / photos / lucasbasquiat

LUCAS AND FAMILY FRIEND CONGRATULATIONS!

Tuesday, June 1, 2010

SSRIs and Suicide

Prozac and suicide: what's going on?

Many people think that SSRI antidepressants do indeed cause suicide, and in recent years this idea has gained a huge amount of attention. My opinion is that, well, it's all rather complicated...

At first glance, it seems as though it should be easy to discover the truth. SSRIs are some of the most studied drugs in the world. We have data from several hundred randomized placebo-controlled trials, totaling tens of thousands of patients. Let's just look and see whether people given SSRIs are more likely to die by suicide than people given placebo.

Unfortunately, that doesn't really work. Actual suicides are extremely rare in antidepressant trials. This is partly because most trials only last 4 to 6 weeks, but also because anyone showing evidence of suicidal tendencies is excluded from the studies at the outset. There just aren't enough suicides to be able to study.

What you can do is to look at attempted suicide, and at "suicidality", meaning suicidal thoughts and self-harming behaviours. Suicidality is more common than actual suicide, so it's easier to research. Here's the bad news: the evidence from a huge number of trials is that compared to placebo, antidepressants do raise the risk of suffering suicidality(1) and of suicide attempts(1) (from 1.1 per 1000 to 2.7 per 1000), when given to people with psychiatric disorders.

There's no good evidence that SSRIs are any worse or any better than other antidepressants, or that any one SSRI stands out as particularly bad(1,2). The risk seems to be worst in younger people: compared to placebo, SSRIs raised suicidality in people below age 25, had no effect in most adults, and lowered it in the oldest age groups(1). This is why SSRIs (and all other antidepressants) now carry a "black box" in the USA, warning about the risk of suicide in young people.

*

This is very troubling. Hang on though. I mentioned that suicidality is an exclusion criterion from pretty much all antidepressant trials. This is for ethical as well as practical reasons: it's considered unethical to give a suicidal person an experimental drug, and it's really impractical to have patients dying during your trial.

Indeed the recorded rate of suicidality in these trials is incredibly tiny: only 0.5% of the psychiatric patients experienced any suicidal ideation or behaviour at all(1). The other 99.5% never so much as thought about it, apparently. If that were representative of the real world it would be great; unfortunately it isn't. Yet what this all means is that antidepressants could not possibly reduce suicidality in these trials, because there's just nothing there to reduce. Even if, in the real world, they prevent loads of suicides, these trials wouldn't show it.

How do you investigate the effects of drugs "in the real world"? By observational studies - instead of recruiting people for a trial, you just look to see what happens to people who are prescribed a certain drug by their doctor. Observational studies have strengths and weaknesses. They're not placebo controlled, but they can be much larger than trials, and they can study the full spectrum of patients.

Observational studies have found very little evidence suggesting that antidepressants cause suicide. Most strikingly, since 1990 when SSRIs were introduced, antidepressant sales have increased enormously, and the suicide rate has fallen steadily; this is true of all Western countries.

More detailed analyses of antidepressant sales vs. suicide rates across time and location have generally either found either no effect, or a small protective effect, of antidepressant sales(1,2,3, many others). In the past few years, concern over suicidality has led to a fall in antidepressant use in adolescents in many countries: but there is no evidence that this reduced the adolescent suicide rate(1,2).

Another observational approach is to see whether people who have actually died by suicide were taking SSRIs at the time of death. Australian psychiatrists Dudley et al have just published a review of the evidence on this question, and they found that out of a total of 574 adolescent suicide victims from the USA, Britain, and Scandinavia, only 9 (1.5%) were taking an SSRI when they died. In other words, the vast majority of youth suicides occur in non-SSRI users. This sets a very low upper limit on the number of suicides that could be caused by SSRIs.


*

So what does all this mean? As I said, it's very controversial, but here's my take, with the standard caveat that I'm just some guy on the internet.

The evidence from randomized controlled trials is clear: SSRIs can cause suicidality, including suicide attempts, in some people, especially people below age 25. The chance of this happening is below 1% according to the trials, but this is still worrying given that lots of people take antidepressants. However, the use of antidepressants on a truly massive scale has not led to any rise in the suicide rate in any age group. This implies that overall, antidepressants prevent at least as many suicides as they cause.

My conclusion is that the clinical trials are not much use when it comes to knowing what will happen to any individual patient. The evidence is that antidepressants could worsen suicidality, or they could reduce it. This is hardly a satisfactory conclusion for people who want neat and tidy answers, but there aren't many of those in psychiatry. For patients, the implication is, boringly, that we should follow the instructions on the packet - be vigilant for suicidality, but don't stop taking them except on a doctor's orders.

ResearchBlogging.orgDudley, M., Goldney, R., & Hadzi-Pavlovic, D. (2010). Are adolescents dying by suicide taking SSRI antidepressants? A review of observational studies Australasian Psychiatry, 18 (3), 242-245 DOI: 10.3109/10398561003681319

SSRIs and Suicide

Prozac and suicide: what's going on?

Many people think that SSRI antidepressants do indeed cause suicide, and in recent years this idea has gained a huge amount of attention. My opinion is that, well, it's all rather complicated...

At first glance, it seems as though it should be easy to discover the truth. SSRIs are some of the most studied drugs in the world. We have data from several hundred randomized placebo-controlled trials, totaling tens of thousands of patients. Let's just look and see whether people given SSRIs are more likely to die by suicide than people given placebo.

Unfortunately, that doesn't really work. Actual suicides are extremely rare in antidepressant trials. This is partly because most trials only last 4 to 6 weeks, but also because anyone showing evidence of suicidal tendencies is excluded from the studies at the outset. There just aren't enough suicides to be able to study.

What you can do is to look at attempted suicide, and at "suicidality", meaning suicidal thoughts and self-harming behaviours. Suicidality is more common than actual suicide, so it's easier to research. Here's the bad news: the evidence from a huge number of trials is that compared to placebo, antidepressants do raise the risk of suffering suicidality(1) and of suicide attempts(1) (from 1.1 per 1000 to 2.7 per 1000), when given to people with psychiatric disorders.

There's no good evidence that SSRIs are any worse or any better than other antidepressants, or that any one SSRI stands out as particularly bad(1,2). The risk seems to be worst in younger people: compared to placebo, SSRIs raised suicidality in people below age 25, had no effect in most adults, and lowered it in the oldest age groups(1). This is why SSRIs (and all other antidepressants) now carry a "black box" in the USA, warning about the risk of suicide in young people.

*

This is very troubling. Hang on though. I mentioned that suicidality is an exclusion criterion from pretty much all antidepressant trials. This is for ethical as well as practical reasons: it's considered unethical to give a suicidal person an experimental drug, and it's really impractical to have patients dying during your trial.

Indeed the recorded rate of suicidality in these trials is incredibly tiny: only 0.5% of the psychiatric patients experienced any suicidal ideation or behaviour at all(1). The other 99.5% never so much as thought about it, apparently. If that were representative of the real world it would be great; unfortunately it isn't. Yet what this all means is that antidepressants could not possibly reduce suicidality in these trials, because there's just nothing there to reduce. Even if, in the real world, they prevent loads of suicides, these trials wouldn't show it.

How do you investigate the effects of drugs "in the real world"? By observational studies - instead of recruiting people for a trial, you just look to see what happens to people who are prescribed a certain drug by their doctor. Observational studies have strengths and weaknesses. They're not placebo controlled, but they can be much larger than trials, and they can study the full spectrum of patients.

Observational studies have found very little evidence suggesting that antidepressants cause suicide. Most strikingly, since 1990 when SSRIs were introduced, antidepressant sales have increased enormously, and the suicide rate has fallen steadily; this is true of all Western countries.

More detailed analyses of antidepressant sales vs. suicide rates across time and location have generally either found either no effect, or a small protective effect, of antidepressant sales(1,2,3, many others). In the past few years, concern over suicidality has led to a fall in antidepressant use in adolescents in many countries: but there is no evidence that this reduced the adolescent suicide rate(1,2).

Another observational approach is to see whether people who have actually died by suicide were taking SSRIs at the time of death. Australian psychiatrists Dudley et al have just published a review of the evidence on this question, and they found that out of a total of 574 adolescent suicide victims from the USA, Britain, and Scandinavia, only 9 (1.5%) were taking an SSRI when they died. In other words, the vast majority of youth suicides occur in non-SSRI users. This sets a very low upper limit on the number of suicides that could be caused by SSRIs.


*

So what does all this mean? As I said, it's very controversial, but here's my take, with the standard caveat that I'm just some guy on the internet.

The evidence from randomized controlled trials is clear: SSRIs can cause suicidality, including suicide attempts, in some people, especially people below age 25. The chance of this happening is below 1% according to the trials, but this is still worrying given that lots of people take antidepressants. However, the use of antidepressants on a truly massive scale has not led to any rise in the suicide rate in any age group. This implies that overall, antidepressants prevent at least as many suicides as they cause.

My conclusion is that the clinical trials are not much use when it comes to knowing what will happen to any individual patient. The evidence is that antidepressants could worsen suicidality, or they could reduce it. This is hardly a satisfactory conclusion for people who want neat and tidy answers, but there aren't many of those in psychiatry. For patients, the implication is, boringly, that we should follow the instructions on the packet - be vigilant for suicidality, but don't stop taking them except on a doctor's orders.

ResearchBlogging.orgDudley, M., Goldney, R., & Hadzi-Pavlovic, D. (2010). Are adolescents dying by suicide taking SSRI antidepressants? A review of observational studies Australasian Psychiatry, 18 (3), 242-245 DOI: 10.3109/10398561003681319