Tuesday, November 30, 2010

Exercise and Depression: It's Complicated

Some ideas seem so nice, so inoffensive and so harmless, that it seems a shame to criticize them.


Take the idea that exercise is a useful treatment for depression. It's got something for everyone.

For doctors, it's attractive because it means they can recommend exercise - which is free, quick, and easy, at least for them - instead of spending the time and money on drugs or therapy. Governments like it for the same reason, and because it's another way of improving the nation's fitness. For people who don't much like psychiatry, exercise offers a lovely alternative to psych drugs - why take those nasty antidepressants if exercise will do just as well? And so on.

But this doesn't mean it's true. And a large observational study from Norway has just cast doubt on it: Physical activity and common mental disorders.

The authors took a large community sample of Norwegian people, the HUNT-2 study, which was done between 1995 and 1997. Over 90,000 people were invited to take part and full data were available from over 40,000.

What they found was that there was an association between taking part in physical exercise as a leisure activity, and lower self-reported symptoms of depression. It didn't matter whether the activity was intense or mild, and it didn't really matter how often you did it: so long as you did it, you got the benefit.

Crucially, however, the same was not true of physical exercise which was part of your job. That didn't help at all, and indeed the most strenuous jobs were associated with more depression (but less anxiety, strangely).

How does this fit with the very popular idea that exercise helps in depression? Well, many randomized trials have indeed
shown exercise to be better than not-exercize for depression
, but the problem is that these trials are never really placebo controlled. You can usually tell whether or not you're going jogging in the park every morning.

So the direct effects of exercise per se are hard to distinguish from the social and psychological meaning of "exercise". Knowing that you're starting a program of exercise could make you feel better: you're taking positive action to improve your life, you're not helpless in the face of your problems. By contrast, doing heavy work as part of your job, while physiologically beneficial, is unlikely to be so much fun.

This doesn't mean that telling people to get more exercise isn't a good idea, but if the meaning of exercise is more important than the physiology, that has some big implications for how it ought to be used.

It's good news for people who just can't take part in strenuous physical exercise because of physical illness or disability, something which is quite common in mental health. It suggests that these people could still get the benefits attributed to exercise even if they did less demanding forms of meaningful activity.

But it's bad news for doctors tempted to default to "get out and go jogging" whenever they see a potentially depressed person. Because if it's the meaning of exercise that counts, and you recommend exercise in a way which sounds like you're dismissing their problems, the meaning will be anything but helpful.

In clinical trials of exercise, the exercise program has, almost by definition, a positive value: it's the whole point of the trial. And the participants just wouldn't have volunteered for the trial if they didn't, on some level, think it would make them feel better.

But not everyone thinks that way. If you go to your doctor looking to get medication, or psychotherapy, or something like that, and you're told that all you need to do is go and get more exercise, it would be easy to see that as a brush-off, especially if it's done unsympathetically. The point is, if exercise doesn't feel like a positive step, it probably won't be one.

ResearchBlogging.orgHarvey SB, Hotopf M, Overland S, & Mykletun A (2010). Physical activity and common mental disorders. The British journal of psychiatry : the journal of mental science, 197, 357-64 PMID: 21037212

Exercise and Depression: It's Complicated

Some ideas seem so nice, so inoffensive and so harmless, that it seems a shame to criticize them.


Take the idea that exercise is a useful treatment for depression. It's got something for everyone.

For doctors, it's attractive because it means they can recommend exercise - which is free, quick, and easy, at least for them - instead of spending the time and money on drugs or therapy. Governments like it for the same reason, and because it's another way of improving the nation's fitness. For people who don't much like psychiatry, exercise offers a lovely alternative to psych drugs - why take those nasty antidepressants if exercise will do just as well? And so on.

But this doesn't mean it's true. And a large observational study from Norway has just cast doubt on it: Physical activity and common mental disorders.

The authors took a large community sample of Norwegian people, the HUNT-2 study, which was done between 1995 and 1997. Over 90,000 people were invited to take part and full data were available from over 40,000.

What they found was that there was an association between taking part in physical exercise as a leisure activity, and lower self-reported symptoms of depression. It didn't matter whether the activity was intense or mild, and it didn't really matter how often you did it: so long as you did it, you got the benefit.

Crucially, however, the same was not true of physical exercise which was part of your job. That didn't help at all, and indeed the most strenuous jobs were associated with more depression (but less anxiety, strangely).

How does this fit with the very popular idea that exercise helps in depression? Well, many randomized trials have indeed
shown exercise to be better than not-exercize for depression
, but the problem is that these trials are never really placebo controlled. You can usually tell whether or not you're going jogging in the park every morning.

So the direct effects of exercise per se are hard to distinguish from the social and psychological meaning of "exercise". Knowing that you're starting a program of exercise could make you feel better: you're taking positive action to improve your life, you're not helpless in the face of your problems. By contrast, doing heavy work as part of your job, while physiologically beneficial, is unlikely to be so much fun.

This doesn't mean that telling people to get more exercise isn't a good idea, but if the meaning of exercise is more important than the physiology, that has some big implications for how it ought to be used.

It's good news for people who just can't take part in strenuous physical exercise because of physical illness or disability, something which is quite common in mental health. It suggests that these people could still get the benefits attributed to exercise even if they did less demanding forms of meaningful activity.

But it's bad news for doctors tempted to default to "get out and go jogging" whenever they see a potentially depressed person. Because if it's the meaning of exercise that counts, and you recommend exercise in a way which sounds like you're dismissing their problems, the meaning will be anything but helpful.

In clinical trials of exercise, the exercise program has, almost by definition, a positive value: it's the whole point of the trial. And the participants just wouldn't have volunteered for the trial if they didn't, on some level, think it would make them feel better.

But not everyone thinks that way. If you go to your doctor looking to get medication, or psychotherapy, or something like that, and you're told that all you need to do is go and get more exercise, it would be easy to see that as a brush-off, especially if it's done unsympathetically. The point is, if exercise doesn't feel like a positive step, it probably won't be one.

ResearchBlogging.orgHarvey SB, Hotopf M, Overland S, & Mykletun A (2010). Physical activity and common mental disorders. The British journal of psychiatry : the journal of mental science, 197, 357-64 PMID: 21037212

Monday, November 29, 2010

Traveling



We're going to be in Texas until next week. For a mariachi and dance workshop. I'm so excited! I really like coming to these things. You meet so many good people. And you learn so much.

I've got all my homework with me. My Dad told me that it's important that I keep up with my school work. I agree. But I'm really excited about performing this week.

My Dad is going to be teaching. And all of my dance group is here too. I'm so excited! We had to bring so much luggage. The airports were so busy. But everyone is happy to be here. :) C

Sunday, November 28, 2010

A LIÇÃO DO BAMBU CHINÊS.

AGRADEÇO A TODOS QUE VIERAM E COMPARTILHARAM DA FESTA DA CHICA NA INTERAÇÃO DE AMIGOS.
QUER CONFERIR UM POUQUINHO...

DEIXO UMA MENSAGEM PARA TODOS NÓS...

A lição do bambu chinês
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

Depois de plantada a semente deste incrível arbusto, não se vê nada, Durante 5 anos, todo o crescimento é subterrâneo, invisível a olho nu, Mas, uma maciça e fibrosa estrutura de raiz, que se estende vertical e horizontalmente pela terra está sendo construída.

Um escritor americano escreveu:

"Muitas coisas na vida pessoal e profissional são iguais ao bambu chinês": você trabalha, investe tempo, esforço, faz tudo o que pode para nutrir seu crescimento,e, às vezes não vê nada por semanas, meses, ou anos.

Mas, se tiver paciência para continuar trabalhando, persistindo e nutrindo, o seu 5º ano chegará, e, com ele, virão um crescimento e mudanças que você jamais esperava...

O bambu chinês nos ensina que não devemos facilmente desistir de nossos projetos,de nossos sonhos... especialmente no nosso trabalho, (que é sempre um grande projeto em nossas vidas)

É que devemos lembrar do bambu chinês, para não desistirmos facilmente diante das dificuldades que surgirão.

Tenha sempre dois hábitos:

Persistência e Paciência, pois você merece alcançar todos os sonhos!!!

É preciso muita fibra para chegar às alturas e, ao mesmo tempo, muita flexibilidade para se curvar ao chão.

( net. google-mensagens)

AGRADEÇO A SUA COMPANHIA!!!Clique Aqui e veja mais imagens

MEUS MIMOS/SEUS PRESENTES- VOU TE ESPERAR POR LÁ.
UM LINDO SELO RECEBIDO -

Sinal de Liberdade-uma expressão de sentimento-

DEIXO O MEU ABRAÇO SUPER CARINHO A TODOS.
PEÇO DESCULPAS Á TODOS EM NÃO PODER VISITÁ-LOS COM FREQUENCIA.
MAS ANDO MESMO SEM TEMPO.
MAS SEI QUE VENS E SEMPRE QUE EU PUDER TAMBÉM IREI.
POIS MORAS NO MEU CORAÇÃO.

Saturday, November 27, 2010

A New Dress

Today my Dad and I drove to the big malls. It's an hour from our house. But we wanted to go have a fun day together.

I wanted to buy some Christmas presents too. So I took my allowance with me. I've been saving it for a long time. And I had my list. I got lots of presents. And something really special for my Nana.

I also bought me something special. A new dress. :)



I found it at Forever 21. And it was $15. I really like it. I think I'm going to wear it for New Year's. My favorite part of the dress is the sleeves. I can't wait to wear it! :) C

The Town That Went Mad

Pont St. Esprit is a small town in southern France. In 1951 it became famous as the site of one of the most mysterious medical outbreaks of modern times.

As Dr's Gabbai, Lisbonne and Pourquier wrote to the British Medical Journal, 15 days after the "incident":
The first symptoms appeared after a latent period of 6 to 48 hours. In this first phase, the symptoms were generalized, and consisted in a depressive state with anguish and slight agitation.

After some hours the symptoms became more clearly defined, and most of the patients presented with digestive disturbances... Disturbances of the autonomic nervous system accompanied the digestive disorders-gusts of warmth, followed by the impression of "cold waves", with intense sweating crises. We also noted frequent excessive salivation.

The patients were pale and often showed a regular bradycardia (40 to 50 beats a minute), with weakness of the pulse. The heart sounds were rather muffled; the extremities were cold... Thereafter a constant symptom appeared - insomnia lasting several days... A state of giddiness persisted, accompanied by abundant sweating and a disagreeable odour. The special odour struck the patient and his attendants.
In most patients, these symptoms, including the total insomnia, persisted for several days. In some of the patients, these symptoms progressed to full-blown psychosis:
Logorrhoea [speaking a lot], psychomotor agitation, and absolute insomnia always presaged the appearance of mental disorders. Towards evening visual hallucinations appeared, recalling those of alcoholism. The particular themes were visions of animals and of flames. All these visions were fleeting and variable.

In many of the patients they were followed by dreamy delirium. The delirium seemed to be systematized, with animal hallucinations and self-accusation, and it was sometimes mystical or macabre. In some cases terrifying visions were followed by fugues, and two patients even threw themselves out of windows... Every attempt at restraint increased the agitation.

In severe cases muscular spasms appeared, recalling those of tetanus, but seeming to be less sustained and less painful... The duration of these periods of delirium was very varied. They lasted several hours in some patients, in others they still persist.
In total, about 150 people suffered some symptoms. About 25 severe cases developed the "delirium". 4 people died "in muscular spasm and in a state of cardiovascular collapse"; three of these were old and in poor health, but one was a healthy 25-year-old man.

At first, the cause was assumed to be ergotism - poisoning caused by chemicals produced by a fungus which can infect grain crops. Contaminated bread was, therefore, thought to be responsible. Ergotism produces symptoms similar to those reported at Pont St. Esprit, including hallucinations, because some of the toxins are chemically related to LSD.

However, there have been other theories. Some (including Albert Hofmann, the inventor of LSD) attribute the poisoning to pesticides containing mercury, or to the flour bleaching agent nitrogen trichloride.

More recently, journalist Hank Albarelli claimed that it was in fact a CIA experiment to test out the effects of LSD as a chemical weapon, though this is disputed. What really happened is, in other words, still a mystery.

Link: The Crazies (2010) is a movie about a remarkably similar outbreak of mass insanity in a small town.

ResearchBlogging.orgGABBAI, LISBONNE, & POURQUIER (1951). Ergot poisoning at Pont St. Esprit. British medical journal, 2 (4732), 650-1 PMID: 14869677

The Town That Went Mad

Pont St. Esprit is a small town in southern France. In 1951 it became famous as the site of one of the most mysterious medical outbreaks of modern times.

As Dr's Gabbai, Lisbonne and Pourquier wrote to the British Medical Journal, 15 days after the "incident":
The first symptoms appeared after a latent period of 6 to 48 hours. In this first phase, the symptoms were generalized, and consisted in a depressive state with anguish and slight agitation.

After some hours the symptoms became more clearly defined, and most of the patients presented with digestive disturbances... Disturbances of the autonomic nervous system accompanied the digestive disorders-gusts of warmth, followed by the impression of "cold waves", with intense sweating crises. We also noted frequent excessive salivation.

The patients were pale and often showed a regular bradycardia (40 to 50 beats a minute), with weakness of the pulse. The heart sounds were rather muffled; the extremities were cold... Thereafter a constant symptom appeared - insomnia lasting several days... A state of giddiness persisted, accompanied by abundant sweating and a disagreeable odour. The special odour struck the patient and his attendants.
In most patients, these symptoms, including the total insomnia, persisted for several days. In some of the patients, these symptoms progressed to full-blown psychosis:
Logorrhoea [speaking a lot], psychomotor agitation, and absolute insomnia always presaged the appearance of mental disorders. Towards evening visual hallucinations appeared, recalling those of alcoholism. The particular themes were visions of animals and of flames. All these visions were fleeting and variable.

In many of the patients they were followed by dreamy delirium. The delirium seemed to be systematized, with animal hallucinations and self-accusation, and it was sometimes mystical or macabre. In some cases terrifying visions were followed by fugues, and two patients even threw themselves out of windows... Every attempt at restraint increased the agitation.

In severe cases muscular spasms appeared, recalling those of tetanus, but seeming to be less sustained and less painful... The duration of these periods of delirium was very varied. They lasted several hours in some patients, in others they still persist.
In total, about 150 people suffered some symptoms. About 25 severe cases developed the "delirium". 4 people died "in muscular spasm and in a state of cardiovascular collapse"; three of these were old and in poor health, but one was a healthy 25-year-old man.

At first, the cause was assumed to be ergotism - poisoning caused by chemicals produced by a fungus which can infect grain crops. Contaminated bread was, therefore, thought to be responsible. Ergotism produces symptoms similar to those reported at Pont St. Esprit, including hallucinations, because some of the toxins are chemically related to LSD.

However, there have been other theories. Some (including Albert Hofmann, the inventor of LSD) attribute the poisoning to pesticides containing mercury, or to the flour bleaching agent nitrogen trichloride.

More recently, journalist Hank Albarelli claimed that it was in fact a CIA experiment to test out the effects of LSD as a chemical weapon, though this is disputed. What really happened is, in other words, still a mystery.

Link: The Crazies (2010) is a movie about a remarkably similar outbreak of mass insanity in a small town.

ResearchBlogging.orgGABBAI, LISBONNE, & POURQUIER (1951). Ergot poisoning at Pont St. Esprit. British medical journal, 2 (4732), 650-1 PMID: 14869677