Tuesday, December 28, 2010

NOSSAS COMPRAS EM DALLAS-TEXAS.

COMPRAS COM DIREITO A TAPETE VERMELHO E TUDO....


COMPRAS PARA O NATAL, AMIGO SECRETO E FILHOS...

NOSSA...E UMA LOUCURA...
COMO TEM COISAS LINDAS..
MUITAS MARCAS...
TUDO MUITO FASHION


ATE COM TAPETE VERMELHO...TUDO MUITO CHIQUE







TUDO ESTA VALENDO A PENA...AGRADECO A DEUS PELO OPORTUNIDADE DESTA BELA VIAGEM...
(LEMBRANDO QUE O PC ESTA CONFIGURADO NA LINGUAGEM INGLESA. POR ISSO NAO CONEGUINDO COLOCAR OS ACENTOS...E OS C CEDILHADOS)

OBRIGADA PELA SUA COMPANHIA. AMO VOCÊ!!!!
AGRADEÇO A SUA COMPANHIA!!!Clique Aqui e veja mais imagens


Blog Coletivo-Uma Interação de Amigos-VENHA VER AS NOVAS FOTOS..VOU TE ESPERAR...


MEUS MIMOS/SEUS PRESENTES- VOU TE ESPERAR POR LÁ.
UM LINDO SELO RECEBIDO -

When Is A Placebo Not A Placebo?

Irving Kirsch, best known for that 2008 meta-analysis allegedly showing that "Prozac doesn't work", has hit the headlines again.

This time it's a paper claiming that something does work. Actually Kirsch is only a minor author on the paper by Kaptchuck et al: Placebos without Deception.

In essence, they asked whether a placebo treatment - a dummy pill with no active ingredients - works even if you know that it's a placebo. Conventional wisdom would say no, because the placebo effect is driven by the patient's belief in the effectiveness of the pill.

Kaptchuck et al took 80 patients with Irritable Bowel Syndrome (IBS) and recruited them into a trial of "a novel mind-body management study of IBS". Half of the patients got no treatment at all. The other half got inert cellulose capsules, after having been told, truthfully, that the pills contained no active drugs but also having been told to expect improvement in a 15 minute briefing session on the grounds that
placebo pills, something like sugar pills, have been shown in rigorous clinical testing to produce significant mind-body self-healing processes.
Guess what? The placebo group did better than the no treatment group, or at least they reported that they did (all the outcomes were subjective). The article has been much blogged about, and you should read those posts for a more detailed and in some cases skeptical examination, but really, this is entirely unsurprising and doesn't challenge the conventional wisdom about placebos.

The folks in this trial believed in the possibility that the pills would make them feel better. They just wouldn't have agreed to take part otherwise. And when those people got the treatment that they expected to work, they felt better. That's just the plain old placebo effect. We already know that the placebo effect is very strong in IBS, a disease which is, at least in many cases, psychosomatic.

So the only really new result here is that there are people out there who'll believe that they'll experience improvement from sugar pills, if you give them a 15 minute briefing about the "mind-body self-healing" properties of those pills. That's an interesting addition to the record of human quirkiness, but it doesn't really tell us anything new about placebos.

ResearchBlogging.orgKaptchuk, T., Friedlander, E., Kelley, J., Sanchez, M., Kokkotou, E., Singer, J., Kowalczykowski, M., Miller, F., Kirsch, I., & Lembo, A. (2010). Placebos without Deception: A Randomized Controlled Trial in Irritable Bowel Syndrome PLoS ONE, 5 (12) DOI: 10.1371/journal.pone.0015591

When Is A Placebo Not A Placebo?

Irving Kirsch, best known for that 2008 meta-analysis allegedly showing that "Prozac doesn't work", has hit the headlines again.

This time it's a paper claiming that something does work. Actually Kirsch is only a minor author on the paper by Kaptchuck et al: Placebos without Deception.

In essence, they asked whether a placebo treatment - a dummy pill with no active ingredients - works even if you know that it's a placebo. Conventional wisdom would say no, because the placebo effect is driven by the patient's belief in the effectiveness of the pill.

Kaptchuck et al took 80 patients with Irritable Bowel Syndrome (IBS) and recruited them into a trial of "a novel mind-body management study of IBS". Half of the patients got no treatment at all. The other half got inert cellulose capsules, after having been told, truthfully, that the pills contained no active drugs but also having been told to expect improvement in a 15 minute briefing session on the grounds that
placebo pills, something like sugar pills, have been shown in rigorous clinical testing to produce significant mind-body self-healing processes.
Guess what? The placebo group did better than the no treatment group, or at least they reported that they did (all the outcomes were subjective). The article has been much blogged about, and you should read those posts for a more detailed and in some cases skeptical examination, but really, this is entirely unsurprising and doesn't challenge the conventional wisdom about placebos.

The folks in this trial believed in the possibility that the pills would make them feel better. They just wouldn't have agreed to take part otherwise. And when those people got the treatment that they expected to work, they felt better. That's just the plain old placebo effect. We already know that the placebo effect is very strong in IBS, a disease which is, at least in many cases, psychosomatic.

So the only really new result here is that there are people out there who'll believe that they'll experience improvement from sugar pills, if you give them a 15 minute briefing about the "mind-body self-healing" properties of those pills. That's an interesting addition to the record of human quirkiness, but it doesn't really tell us anything new about placebos.

ResearchBlogging.orgKaptchuk, T., Friedlander, E., Kelley, J., Sanchez, M., Kokkotou, E., Singer, J., Kowalczykowski, M., Miller, F., Kirsch, I., & Lembo, A. (2010). Placebos without Deception: A Randomized Controlled Trial in Irritable Bowel Syndrome PLoS ONE, 5 (12) DOI: 10.1371/journal.pone.0015591

Monday, December 27, 2010

Does Peer Review Work?

Scientific peer review is based on the idea that some papers deserve to get published and others don't.

By asking a hand-picked team of 3 or 4 experts in the field (the "peers"), journals hope to accept the good stuff, filter out the rubbish, and improve the not-quite-good-enough papers.

This all assumes that the reviewers, being experts, are able to make a more or less objective judgement. In other words, when a reviewer says that a paper's good or bad, they're reporting something about the paper, not just giving their own personal opinion.

If that's true, reviewers ought to agree with each other about the merits of each paper. On the other hand, if it turns out that they don't agree any more often than we'd expect if they were assigning ratings entirely at random, that would suggest that there's a problem somewhere.

Guess what? Bornmann et al have just reported that reviewers are only slightly more likely to agree than they would be if they were just flipping coins: A Reliability - Generalization Study of Journal Peer Reviews.

The study is a meta-analysis of 48 studies published since 1966, looking at peer review of either journal papers or conference presentations. In total, almost 20,000 submissions were studied. Bornmann et al calculated the mean inter-rater reliability (IRR), a measure of how well different judges agree with each other.

Overall, they found a reliability coefficient (r^2) of 0.23, or 0.34 under a different statistical model. This is pretty low, given that 0 is random chance, while a perfect correlation would be 1.0. Using another measure of IRR, Cohen's kappa, they found a reliability of 0.17. That means that peer reviewers only agreed on 17% more manuscripts than they would by chance alone.

Worse still, the bigger the study, the worse the reliability it reported. On the other hand, the subject - economics/law, natural sciences, medical sciences, or social sciences - had no effect, arguing against the common sense idea that reviews must be more objective in the "harder" sciences.

So what? Does this mean that peer review is a bad thing? Maybe it's like the police. The police are there to prevent and punish crime. They don't always succeed: crime happens. But only a fool would argue that, because the police fail to prevent some crimes, we ought to abolish them. The fact that we have police, even imperfect ones, acts a deterrent.

Likewise, I suspect that peer review, for all its flaws (and poor reliability is just one of them), does prevent many "bad" papers from getting written, or getting submitted, even if a lot do still make it through, and even if the vetting process is not itself not very efficient. The very fact that peer review is there at all, makes people write their papers in a certain way.

Peer review surely does "work", to some extent - but is the work it does actually useful? Does it really filter out bad papers or does it on the contrary act to stifle originality? There are lots of things to say about this, but I will just say this for now: it's important to distinguish between whether peer review is good for science as a whole, and whether it's good for journals.

Every respectable journal relies on peer review to decide which papers to publish: even if the reviewers achieve nothing else, they certainly save the Editor time, and hence money (reviewers generally work for free). It's very hard to see how the current system of scientific publication in journals would survive without peer review. But that doesn't mean it's good for science. That's an entirely different question.

ResearchBlogging.orgBornmann L, Mutz R, & Daniel HD (2010). A reliability-generalization study of journal peer reviews: a multilevel metaanalysis of interrater reliability and its determinants. PloS ONE, 5 (12) PMID: 21179459

Does Peer Review Work?

Scientific peer review is based on the idea that some papers deserve to get published and others don't.

By asking a hand-picked team of 3 or 4 experts in the field (the "peers"), journals hope to accept the good stuff, filter out the rubbish, and improve the not-quite-good-enough papers.

This all assumes that the reviewers, being experts, are able to make a more or less objective judgement. In other words, when a reviewer says that a paper's good or bad, they're reporting something about the paper, not just giving their own personal opinion.

If that's true, reviewers ought to agree with each other about the merits of each paper. On the other hand, if it turns out that they don't agree any more often than we'd expect if they were assigning ratings entirely at random, that would suggest that there's a problem somewhere.

Guess what? Bornmann et al have just reported that reviewers are only slightly more likely to agree than they would be if they were just flipping coins: A Reliability - Generalization Study of Journal Peer Reviews.

The study is a meta-analysis of 48 studies published since 1966, looking at peer review of either journal papers or conference presentations. In total, almost 20,000 submissions were studied. Bornmann et al calculated the mean inter-rater reliability (IRR), a measure of how well different judges agree with each other.

Overall, they found a reliability coefficient (r^2) of 0.23, or 0.34 under a different statistical model. This is pretty low, given that 0 is random chance, while a perfect correlation would be 1.0. Using another measure of IRR, Cohen's kappa, they found a reliability of 0.17. That means that peer reviewers only agreed on 17% more manuscripts than they would by chance alone.

Worse still, the bigger the study, the worse the reliability it reported. On the other hand, the subject - economics/law, natural sciences, medical sciences, or social sciences - had no effect, arguing against the common sense idea that reviews must be more objective in the "harder" sciences.

So what? Does this mean that peer review is a bad thing? Maybe it's like the police. The police are there to prevent and punish crime. They don't always succeed: crime happens. But only a fool would argue that, because the police fail to prevent some crimes, we ought to abolish them. The fact that we have police, even imperfect ones, acts a deterrent.

Likewise, I suspect that peer review, for all its flaws (and poor reliability is just one of them), does prevent many "bad" papers from getting written, or getting submitted, even if a lot do still make it through, and even if the vetting process is not itself not very efficient. The very fact that peer review is there at all, makes people write their papers in a certain way.

Peer review surely does "work", to some extent - but is the work it does actually useful? Does it really filter out bad papers or does it on the contrary act to stifle originality? There are lots of things to say about this, but I will just say this for now: it's important to distinguish between whether peer review is good for science as a whole, and whether it's good for journals.

Every respectable journal relies on peer review to decide which papers to publish: even if the reviewers achieve nothing else, they certainly save the Editor time, and hence money (reviewers generally work for free). It's very hard to see how the current system of scientific publication in journals would survive without peer review. But that doesn't mean it's good for science. That's an entirely different question.

ResearchBlogging.orgBornmann L, Mutz R, & Daniel HD (2010). A reliability-generalization study of journal peer reviews: a multilevel metaanalysis of interrater reliability and its determinants. PloS ONE, 5 (12) PMID: 21179459

Sunday, December 26, 2010

NOSSO AMIGO SECRETO



NATAL COM PRESENTE NO AMIGO SECRETO.





NOSSA NOITE DE NATAL-
CEIA EXATAMENTE A MEIA NOITE.

Friday, December 24, 2010

CURIOSA DESEJA UM FELIZ NATAL...

UM NATAL DIFERENTE E MARAVILHOSO.
JUNTO A NEVE AO FRIO.

MAS COM A ALEGRIA DE UM NATAL NOS ESTADOS UNIDOS..













DESEJO FELIZ NATAL A TODOS...