Wednesday, February 2, 2011

Pharma: Tamed But Still A Big Beast

Everyone knows that Big Pharma go around lying, concealing data and distorting science in an effort to sell their pills. Right?

Actually, not so much. They used to, but most of the really scandalous stuff happened many years ago. The late 80's through to about the turn of the century were the Golden Age of pharmaceutical company deception.

This is when we had drugs that don't work getting approved, with the trials showing that they don't work buried, and only now being uncovered. Data on drug-induced suicides seemingly fudged to make them seem less scary. Textbooks "written by" leading psychiatrists that were, allegedly, in fact ghost-written on behalf of drug companies. Ghost-writing programs with chuckle-some names like CASPPER. And so on.

But today, we have to give credit where credit's due: things have improved. Credit is due not to the companies but to the authorities who put a stop to this nonsense through rules. Mandatory clinical trial registration to ensure all the data is available and stop outcoming cherrypicking. Anti-ghostwriting rules (albeit they're not universal yet.) etc.

What's shocking is how long it took to get these simple rules in place. The next generation of scientists and doctors will look back on the 1990s with disbelief: they let them do what? But at least we woke up eventually.

Still, there's more left to do. At the moment, the main problem, as I see it, is that different jurisdictions have different rules, with the best ideas being confined to one particular place. For instance, the USA has by far the most sensible system of clinical trial registration and reporting. Europe needs to catch up (we are, but slowly.)

Yet the USA is also one of the only countries (with New Zealand) to permit direct-to-consumer (DTC) advertising for prescription drugs. To the rest of the world, this is really weird. We all have a right to free speech. But drug companies pushing drugs directly to patients just isn't a free speech issue, in Europe. Corporations don't speak, they advertise.

By encouraging self-diagnosis and self-treatment, DTC replaces medical judgement with marketing, undermining the doctor-patient relationship. The patient is meant to present his symptoms and the doctor is meant to make a diagnosis and prescribe a treatment. DTC encourages self-diagnosis and self-prescription: the fact that a doctor is still, technically, in charge and has to sign that prescription, means little in practice.

So there's a lot to be happy about, but there's also a lot still to do.

Pharma: Tamed But Still A Big Beast

Everyone knows that Big Pharma go around lying, concealing data and distorting science in an effort to sell their pills. Right?

Actually, not so much. They used to, but most of the really scandalous stuff happened many years ago. The late 80's through to about the turn of the century were the Golden Age of pharmaceutical company deception.

This is when we had drugs that don't work getting approved, with the trials showing that they don't work buried, and only now being uncovered. Data on drug-induced suicides seemingly fudged to make them seem less scary. Textbooks "written by" leading psychiatrists that were, allegedly, in fact ghost-written on behalf of drug companies. Ghost-writing programs with chuckle-some names like CASPPER. And so on.

But today, we have to give credit where credit's due: things have improved. Credit is due not to the companies but to the authorities who put a stop to this nonsense through rules. Mandatory clinical trial registration to ensure all the data is available and stop outcoming cherrypicking. Anti-ghostwriting rules (albeit they're not universal yet.) etc.

What's shocking is how long it took to get these simple rules in place. The next generation of scientists and doctors will look back on the 1990s with disbelief: they let them do what? But at least we woke up eventually.

Still, there's more left to do. At the moment, the main problem, as I see it, is that different jurisdictions have different rules, with the best ideas being confined to one particular place. For instance, the USA has by far the most sensible system of clinical trial registration and reporting. Europe needs to catch up (we are, but slowly.)

Yet the USA is also one of the only countries (with New Zealand) to permit direct-to-consumer (DTC) advertising for prescription drugs. To the rest of the world, this is really weird. We all have a right to free speech. But drug companies pushing drugs directly to patients just isn't a free speech issue, in Europe. Corporations don't speak, they advertise.

By encouraging self-diagnosis and self-treatment, DTC replaces medical judgement with marketing, undermining the doctor-patient relationship. The patient is meant to present his symptoms and the doctor is meant to make a diagnosis and prescribe a treatment. DTC encourages self-diagnosis and self-prescription: the fact that a doctor is still, technically, in charge and has to sign that prescription, means little in practice.

So there's a lot to be happy about, but there's also a lot still to do.

Tuesday, February 1, 2011

OLA MEUS QUERIDOS AMIGOS.



QUERO PEDIR UM MILHÃO DE DESCULPAS, POIS NÃO ESTOU CONSEGUINDO TER TEMPO PARA VISITÁ-LOS.
PASSEI UNS DIAS NA CASA DE MEUS PAIS. MEU PAI ESTA DOENTE. COMO FIQUEI MUITO TEMPO FORA, FUI FAZER UM CARINHO NELES.
A FAMÍLIA TAMBÉM É FUNDAMENTAL..
AGORA ESTOU TRABALHANDO DE NOVO. A VIDA RECOMEÇA COM O ANO NOVO...E MUITA CORRERIA NO DIA -A - DIA DE NOSSA VIDA...
AGRADEÇO DO FUNDO DO MEU CORAÇÃO A VISITA DE TODOS.
AMO CADA UM DE VOCÊS.
SEI QUE NÃO CONSEGUIREI MAIS VIR TODOS OS DIAS. MAS TENHAM A CERTEZA, DE QUE TODOS MORAM NO MEU CORAÇÃO....
CARINHOSAMENTE..SANDRA

FIQUE COM NOVAS IMAGENS DA VIAGEM...




NOVA YORK..MUITO FRIO..MUITA NEVE...


VISITANDO SEA WORD..UM FANTASTICO SHOW COM OS ANIMAIS..
SHOW DAS BALEIAS..SUPER LINDO...
PRAIA DE CORONADO- SAO DIEGO.USA E SANDRA
PÔR DO SOL..SAO DIEGO- CALIFORNIA

AGRADEÇO DO FUNDO DO MEU CORAÇÃO PELA A SUA AMIZADE. ASSIM QUE PUDER POSTAREI MAIS UM POUQUINHO DA VIAGEM. FICO MEU ABRAÇO SUPER APERTADINHO PARA TODOS.

MUITO OBRIGADA PELA SUA COMPANHIA.

Monday, January 31, 2011

Can You Use Expired Face Gel?

story of a table ...



And now a tale of furniture ... but I have forgotten to put the second part of the trunk of keko, with more pictures and details. It will be next week.
Now I want to tell you that a while ago I painted some flowers with oil on wood for a kitchen table.



way it was before upholstered chairs ...



In the first photo of this entry you can see what the whole but soon the table structure failed and had bad deal and then I found some legs on a coffee table but lacked the glass. The solution was to build on the tabletop in the kitchen to the table and buy in ikea pine table untreated. Painted white legs and left the board in the color that matched the chairs and these are the final results. Hope you like.


Does Tiffany Towers Smoke Cigarettes

My friend Noel, a woman artist.


This Christmas I received a wonderful gift and even a little late to share it with you / as I want to do it. Do you see these wonderful tiles? because of the poppies is my thanks to Noel , which is unique by giving gifts and know to be there when you need it. Thank you, friend.

Where Can Read Naruto Yaoi

new prize,


This blog remains for me a wonderful haven where you always find a reason to rejoice, a follower, your comments and from time to time, any awards that come from people who appreciate me very excited. And this is the case of Regina's blog http://farfaladecora.blogspot.com / which has so much talent and adds the courage to put a workshop and store and a living. Thanks, Carinet. You have to make a trip to Oviedo just to meet you.

And I have to tell seven more stuff to know and there you go:
- I get excited easily. With Christmas ads almond and even The Simpsons, if I have a day flojillo ...
- need to work order. Then loose things so quiet anywhere, but if I have to focus I need.
- I admire people who can wear (and do) jewelry and ornaments in general, but I'm a mess and I do not wear anything.
- it relaxes me doing puzzles, crosswords .... mental fitness!
- unfortunately for me, I'm greedy, we're going to do. Luckily I love the vegetables.
- believe that certain objects have their own life (why it I like both "Toy Story"?)
- and as the mother of Amelie, often empty my bag, I order everything and refill ...

and finally, you know I always customize awards but now I really would like to share with each and every one of the blogs I follow. So if I am fan of yours, the prize is for you.