Wednesday, February 9, 2011

Antidepressants Don't Work...In Fish

Here at Neuroskeptic fMRI scanning and antidepressants are both big topics.


As I discussed lask week, fish - specifically salmon - are the next big thing in fMRI and the number of salmon brains being scanned is growing at a remarkable rate. But fish haven't made much of an entrance into the world of antidepressants...until now.

Swedish scientists Holmberg et al have just published a paper asking: Does waterborne citalopram affect the aggressive and sexual behaviour of rainbow trout and guppy?

SSRI antidepressants, of which citalopram is one, are very popular. So popular, in fact, that non-trivial levels of SSRIs have been found in sewage and there's a concern that they might make their way into lakes and rivers and thereby affect the behaviour of the animals living there.

Holmberg et al set out to see what citalopram did to some fish in an attempt to find out whether this is likely to be a major problem. So they put some citalopram in the fish's water supplies and then tested their aggressiveness and also their sex drives. It turns out that one of the main ways of measure fish aggression is to put a mirror in their tank and see if they try to fight their own reflection. Fish are not very bright, really.

Anyway, the good news for fish everywhere was that seven days of citalopram exposure had no effect at all, even at doses much higher than those reported as a pollutant (the maximum dose was 0.1 mg/l). And the authors had no conflicts of interest: Big Pharma had nothing to do with this research, although Big Fish Farmer did because they bought the fish from one.

However, this may not be the end of the story, because it turned out that citalopram was very poorly absorbed into the fish's bloodstreams. But other antidepressants have been reported to accumulate in fish. Clearly, the only way to find out for sure what's going on would be to use fMRI...

ResearchBlogging.orgHolmberg A, Fogel J, Albertsson E, Fick J, Brown JN, Paxéus N, Förlin L, Johnsson JI, & Larsson DG (2011). Does waterborne citalopram affect the aggressive and sexual behaviour of rainbow trout and guppy? Journal of hazardous materials PMID: 21300431

Antidepressants Don't Work...In Fish

Here at Neuroskeptic fMRI scanning and antidepressants are both big topics.


As I discussed lask week, fish - specifically salmon - are the next big thing in fMRI and the number of salmon brains being scanned is growing at a remarkable rate. But fish haven't made much of an entrance into the world of antidepressants...until now.

Swedish scientists Holmberg et al have just published a paper asking: Does waterborne citalopram affect the aggressive and sexual behaviour of rainbow trout and guppy?

SSRI antidepressants, of which citalopram is one, are very popular. So popular, in fact, that non-trivial levels of SSRIs have been found in sewage and there's a concern that they might make their way into lakes and rivers and thereby affect the behaviour of the animals living there.

Holmberg et al set out to see what citalopram did to some fish in an attempt to find out whether this is likely to be a major problem. So they put some citalopram in the fish's water supplies and then tested their aggressiveness and also their sex drives. It turns out that one of the main ways of measure fish aggression is to put a mirror in their tank and see if they try to fight their own reflection. Fish are not very bright, really.

Anyway, the good news for fish everywhere was that seven days of citalopram exposure had no effect at all, even at doses much higher than those reported as a pollutant (the maximum dose was 0.1 mg/l). And the authors had no conflicts of interest: Big Pharma had nothing to do with this research, although Big Fish Farmer did because they bought the fish from one.

However, this may not be the end of the story, because it turned out that citalopram was very poorly absorbed into the fish's bloodstreams. But other antidepressants have been reported to accumulate in fish. Clearly, the only way to find out for sure what's going on would be to use fMRI...

ResearchBlogging.orgHolmberg A, Fogel J, Albertsson E, Fick J, Brown JN, Paxéus N, Förlin L, Johnsson JI, & Larsson DG (2011). Does waterborne citalopram affect the aggressive and sexual behaviour of rainbow trout and guppy? Journal of hazardous materials PMID: 21300431

Tuesday, February 8, 2011

The Social Network and Anorexia

Could social networks be more important than the media in the spread of eating disorders?

There's a story about eating disorders roughly like this: eating disorders (ED) are about wanting to be thin. The idea that thinness is desireable is something that's spread by Western media, especially visual media i.e. TV and magazines. Therefore, Western media exposure causes eating disorders.

It's a nice simple theory. And it seems to fit with the fact that eating disorders, hitherto very rare, start to appear in a certain country in conjunction with the spread of Westernized media. A number of studies have shown this. However, a new paper suggests that there may be rather more to it: Social network media exposure and adolescent eating pathology in Fiji.

Fiji is a former British colony, a tropical island nation of less than a million. Just over half the population are ethnic native Fijian people. Until recently, these Fijians were relatively untouched by Western culture, but this is starting to change.

The authors of this study surveyed 523 Fijian high school girls. Interviews took place in 2007. They asked them various questions relating to, one the one hand, eating disorder symptoms, and on the other hand, their exposure to various forms of media.

They looked at both individual exposure - hours of TV watched, electronic entertainment in the home - and "indirect" or "social network" exposure, such as TV watched by the parents, and the amount of electronic entertainment their friends owned. On top of this they measured Westernization/"globalization", such as the amount of overseas travel by the girls or their parents.

So what happened? Basically, social network media exposure, urbanization, and Westernization correlated with ED symptoms, but when you controlled for those variables, personal media exposure didn't correlate. Here's the data; the column I've highlighted is the data where each variable is controlled for the others. The correlations are pretty small (0 is none, 1.0 would be perfect) but significant.


They conclude that:
Although consistent with the prevailing sociocultural model for the relation between media exposure and disordered eating... our finding, that indirect exposure to media content may be even more influential than direct exposure in this particular social context, is novel.
The idea that eating disorders are simply a product of a culture which values thinness as attractive has always seemed a bit shaky to me because people with anorexia frequently starve themselves far past the point of being attractive even by the unrealistic standards of magazines and movies.

In fact, if eating disorders were just an attempt to "look good", they wouldn't be nearly so dangerous as they are, because no matter how thin-obsessed our culture may be, no-one thinks this is attractive, or normal, or sane. But this, or worse, is what a lot of anorexics end up as.

On the other hand, eating disorders are associated with modern Western culture. There must be a link, but maybe it's more complicated than just "thin = good" causes anorexia. What if you also need the idea of "eating disorders"?

This was the argument put forward by Ethan Watters in Crazy Like Us (my review)... in his account of the rise of anorexia in Hong Kong. Essentially, he said, anorexia was vanishingly rare in Hong Kong until after the much-publicized death of a 14 year old girl, Charlene Chi-Ying, in the street. As he put it:
In trying to explain what happened to Charlene, local reporters often simply copied out of American diagnostic manuals. The mental-health experts quoted in the Hong Kong papers and magazines confidently reported that anorexia in Hong Kong was the same disorder that appeared in the United States and Europe...

As the general public and the region's mental-health professionals came to understand the American diagnosis of anorexia, the presentation of the illness in [Hong Kong psychiatrist] Lee's patient population appeared to transform into the more virulent American standard. Lee once saw two or three anorexic patients a year; by the end of the 1990s he was seeing that many new cases each month.
Now it's important not to see this as trivializing the condition or as a way of blaming the victim; "they're just following a trend!". You only have to look at someone with anorexia to see that there is nothing trivial about it. However, that doesn't mean it's not a social phenomenon.

It's a long way from the data in this study to Watters' conclusions, but maybe not an impossible leap. Part of Westernization, after all, is exposure to Western ideas about what is healthy eating and what's an eating disorder...

ResearchBlogging.orgBecker, A., Fay, K., Agnew-Blais, J., Khan, A., Striegel-Moore, R., & Gilman, S. (2011). Social network media exposure and adolescent eating pathology in Fiji The British Journal of Psychiatry, 198 (1), 43-50 DOI: 10.1192/bjp.bp.110.078675

The Social Network and Anorexia

Could social networks be more important than the media in the spread of eating disorders?

There's a story about eating disorders roughly like this: eating disorders (ED) are about wanting to be thin. The idea that thinness is desireable is something that's spread by Western media, especially visual media i.e. TV and magazines. Therefore, Western media exposure causes eating disorders.

It's a nice simple theory. And it seems to fit with the fact that eating disorders, hitherto very rare, start to appear in a certain country in conjunction with the spread of Westernized media. A number of studies have shown this. However, a new paper suggests that there may be rather more to it: Social network media exposure and adolescent eating pathology in Fiji.

Fiji is a former British colony, a tropical island nation of less than a million. Just over half the population are ethnic native Fijian people. Until recently, these Fijians were relatively untouched by Western culture, but this is starting to change.

The authors of this study surveyed 523 Fijian high school girls. Interviews took place in 2007. They asked them various questions relating to, one the one hand, eating disorder symptoms, and on the other hand, their exposure to various forms of media.

They looked at both individual exposure - hours of TV watched, electronic entertainment in the home - and "indirect" or "social network" exposure, such as TV watched by the parents, and the amount of electronic entertainment their friends owned. On top of this they measured Westernization/"globalization", such as the amount of overseas travel by the girls or their parents.

So what happened? Basically, social network media exposure, urbanization, and Westernization correlated with ED symptoms, but when you controlled for those variables, personal media exposure didn't correlate. Here's the data; the column I've highlighted is the data where each variable is controlled for the others. The correlations are pretty small (0 is none, 1.0 would be perfect) but significant.


They conclude that:
Although consistent with the prevailing sociocultural model for the relation between media exposure and disordered eating... our finding, that indirect exposure to media content may be even more influential than direct exposure in this particular social context, is novel.
The idea that eating disorders are simply a product of a culture which values thinness as attractive has always seemed a bit shaky to me because people with anorexia frequently starve themselves far past the point of being attractive even by the unrealistic standards of magazines and movies.

In fact, if eating disorders were just an attempt to "look good", they wouldn't be nearly so dangerous as they are, because no matter how thin-obsessed our culture may be, no-one thinks this is attractive, or normal, or sane. But this, or worse, is what a lot of anorexics end up as.

On the other hand, eating disorders are associated with modern Western culture. There must be a link, but maybe it's more complicated than just "thin = good" causes anorexia. What if you also need the idea of "eating disorders"?

This was the argument put forward by Ethan Watters in Crazy Like Us (my review)... in his account of the rise of anorexia in Hong Kong. Essentially, he said, anorexia was vanishingly rare in Hong Kong until after the much-publicized death of a 14 year old girl, Charlene Chi-Ying, in the street. As he put it:
In trying to explain what happened to Charlene, local reporters often simply copied out of American diagnostic manuals. The mental-health experts quoted in the Hong Kong papers and magazines confidently reported that anorexia in Hong Kong was the same disorder that appeared in the United States and Europe...

As the general public and the region's mental-health professionals came to understand the American diagnosis of anorexia, the presentation of the illness in [Hong Kong psychiatrist] Lee's patient population appeared to transform into the more virulent American standard. Lee once saw two or three anorexic patients a year; by the end of the 1990s he was seeing that many new cases each month.
Now it's important not to see this as trivializing the condition or as a way of blaming the victim; "they're just following a trend!". You only have to look at someone with anorexia to see that there is nothing trivial about it. However, that doesn't mean it's not a social phenomenon.

It's a long way from the data in this study to Watters' conclusions, but maybe not an impossible leap. Part of Westernization, after all, is exposure to Western ideas about what is healthy eating and what's an eating disorder...

ResearchBlogging.orgBecker, A., Fay, K., Agnew-Blais, J., Khan, A., Striegel-Moore, R., & Gilman, S. (2011). Social network media exposure and adolescent eating pathology in Fiji The British Journal of Psychiatry, 198 (1), 43-50 DOI: 10.1192/bjp.bp.110.078675

Monday, February 7, 2011

ANO LETIVO...2011

http://t1.gstatic.com/images?q=tbn:ANd9GcQhY33-BGOXXK9pjGndz6VRU8NvyPfplyrnYvWT9pjTai24gp8IfQ

VOLTA A AULAS...COMO É BOM RECEBER ALUNOS NOVOS.

CARINHAS DE ALEGRIAS E SATISFAÇÃO..
ENTRE UM CHORO E OUTRO A COMUNIDADE ESCOLAR TOMA SEU NINHO....


" UM TRABALHO ESCOLAR BEM FEITO LIVRARÁ O FUTURO ADULTO DE TER UMA CARÊNCIA PESSOAL DE SEUS PRINCÍPIOS E SENTIMENTOS, PERMITINDO QUE ENCONTRE EM SI MESMO SEGURANÇA E AUTOCONFIANÇA, SEM TER QUE RECORRER DESESPERADAMENTE AOS TERAPEUTAS E LIVROS DE AUTOAJUDA".

A TODOS OS PROFESSORES UM BOM ANO LETIVO.
FELIZ REGRESSO A TODOS. QUE NOSSOS ALUNOS SEJAM ABENÇOADOS POR DEUS.
BEM COMO O PROFESSORES..AMÉM..

AGRADEÇO A SUA COMPANHIA!!!Clique Aqui e veja mais imagens




MEUS MIMOS/SEUS PRESENTES- VOU TE ESPERAR POR LÁ.


Sinal de Liberdade-uma expressão de sentimento-

AMANHÃ É O ANIVER DA ANA. NÃO SEI ONDE ELA ANDA. MAS DESDE JÁ AMIGA, LHE DESEJO UM FELIZ ANIVERSÁRIO.
08 DE FEVEREIRO- UM DIA MUITO ESPECIAL MINHA DOCE AMIGA...
FELIZ ANIVERSÁRIO

Blog Pelos Caminhos da Vida

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clik na foto para ir para meu blog

Stretchy Mucus Around Time For Period

Keko Baul.



Sorry for the delay in putting these photos missing from the trunk that I made with cartoons keko. I hope you now fully appreciate the finish I gave the trunk. These two photos, above and the following are the top:



This is the other side that I needed to show:



And finally, you saw that I lined with dm in sheets but could not show how the inside was painted white.


I hope, as always, that you like. Kisses to all / as

Cool Low Cut Wrestling Singlets

Part 2 Some Like It Hot ...


Therapy: when you do not "block" anything that they throw out the TV revisits a classic. Especially if you run a perfect movie like this, where there are no hits as possible. All of it is wonderful (the movie, which for more than one with Marilyn plans on the rest). It is funny, witty, has good photography, good music, good performances, anthology talks ... come on, you have to see it all the time it takes to not miss a single detail. And if anyone does not see, I hope you enjoy.