Poetas-Um Voo Livre
(Tem selo para vc.)
Sinal de Liberdade-uma expressão de sentimento
(Tem selo para vc.)
Blog Coletivo-Uma Interação de Amigos-
O QUE FAZER PARA TRANSFORMAR E FAZER UM MUNDO MELHOR?
They're weight loss drugs, and with obesity rates rising and the diet craze showing no signs of abating, that's a large and growing market (...sorry). They worked, at least in the short term, and they were at least as effective as existing pills. They may even have had health benefits over and above promoting weight loss, such as improving blood fat and sugar levels through metabolic effects.
But there were side effects. Alongside things like nausea, vomiting, and sweating, about 35% of people taking high doses of taranabant reported "psychiatric disorders". 20% of people on placebo also did, so this is not quite as bad as it first appears, but it's still striking, especially since a number of people on high doses of taranabant reported suicidal thoughts or behaviours...
Suicidal ideation was reported in three patients in the taranabant 6-mg group in year 1 and in one patient in the 4-mg group in year 2. There was one suicide attempt reported in a patient with a previous history of suicide attempts in the 6/2-mg group while the patient was receiving 2-mg, and one episode of suicidal behavior reported in a patient in the 6/2-mg group while the patient was receiving 6-mg. There were no completed suicides. The adjudication of possibly suicide-related adverse experiences during years 1 and 2 indicated an increased incidence of suicidality in the taranabant groups...
Aronne, L., Tonstad, S., Moreno, M., Gantz, I., Erondu, N., Suryawanshi, S., Molony, C., Sieberts, S., Nayee, J., Meehan, A., Shapiro, D., Heymsfield, S., Kaufman, K., & Amatruda, J. (2010). A clinical trial assessing the safety and efficacy of taranabant, a CB1R inverse agonist, in obese and overweight patients: a high-dose study International Journal of Obesity DOI: 10.1038/ijo.2010.21
They're weight loss drugs, and with obesity rates rising and the diet craze showing no signs of abating, that's a large and growing market (...sorry). They worked, at least in the short term, and they were at least as effective as existing pills. They may even have had health benefits over and above promoting weight loss, such as improving blood fat and sugar levels through metabolic effects.But there were side effects. Alongside things like nausea, vomiting, and sweating, about 35% of people taking high doses of taranabant reported "psychiatric disorders". 20% of people on placebo also did, so this is not quite as bad as it first appears, but it's still striking, especially since a number of people on high doses of taranabant reported suicidal thoughts or behaviours...Suicidal ideation was reported in three patients in the taranabant 6-mg group in year 1 and in one patient in the 4-mg group in year 2. There was one suicide attempt reported in a patient with a previous history of suicide attempts in the 6/2-mg group while the patient was receiving 2-mg, and one episode of suicidal behavior reported in a patient in the 6/2-mg group while the patient was receiving 6-mg. There were no completed suicides. The adjudication of possibly suicide-related adverse experiences during years 1 and 2 indicated an increased incidence of suicidality in the taranabant groups...
Aronne, L., Tonstad, S., Moreno, M., Gantz, I., Erondu, N., Suryawanshi, S., Molony, C., Sieberts, S., Nayee, J., Meehan, A., Shapiro, D., Heymsfield, S., Kaufman, K., & Amatruda, J. (2010). A clinical trial assessing the safety and efficacy of taranabant, a CB1R inverse agonist, in obese and overweight patients: a high-dose study International Journal of Obesity DOI: 10.1038/ijo.2010.21
MOMENTOS MUITOS ESPECIAIS..QUE VIVERÃO PARA SEMPRE NAS NOSSAS LEMBRANÇAS...DOCES MOMENTOS DA VIDA...ESSES NINGUÉM NOS TIRA....
Meus Mimos-VOU TE ESPERAR LÁ. CURIOSA AGRADECE...
Poetas-Um Voo Livre
(Tem selo para vc.)
Sinal de Liberdade-uma expressão de sentimento
(Tem selo para vc.)
Blog Coletivo-Uma Interação de Amigos-
PARA QUEM VAI O SEU OSCAR????
(imagem ilustrativa do presente)
NÃO DEIXE DE PEGAR SEUS PRESENTES...
OBRIGADA ANA, PELO CARINHO DEIXADO ONTEM...
Pelos caminhos da vida. disse...Que seu dia seja realmente um otimo dia...
Que suas horas sejam cheias de felicidades...
Que seu entardecer seja o mais maravilhoso...
Que o seu anoitecer seja carinhosamente depositado por Deus!
(Vilma Galvão).
NÃO DEIXE DE PEGAR SEUS PRESENTES...
ENQUANTO ISSO..LEVEM O MEU CORAÇÃO...
The study had a double-blind, placebo-controlled phase: the patients weren't told when the DBS electrodes were going to be switched on. As the graphs show, in the 3 patients who were randomly selected to have them switched on early, 2 responded pretty much immediately, while in the 3 patients whose electrodes were left off, none responded until they were turned on 30 days later, although the response at this point was fairly gradual.Finding the optimal settings for an individual subject proved challenging...unlike other experiences with DBS, there is not a clear positive symptom (e.g., tremor improvement) to gauge settings. In this study... the goal was to select parameters that produced some benefit in mood or anxiety symptoms acutely, with minimal side effects.
Worsening in mood or increased anxiety were typically the first symptoms reported following battery depletion or inadvertent inactivation by metal detectors. Other signs of depression, such as diminished energy or interest, also emerged within days of device interruption... Exacerbation of OCD symptoms generally lagged the emergence of affective or anxiety symptoms.
Goodman, W., Foote, K., Greenberg, B., Ricciuti, N., Bauer, R., Ward, H., Shapira, N., Wu, S., Hill, C., & Rasmussen, S. (2010). Deep Brain Stimulation for Intractable Obsessive Compulsive Disorder: Pilot Study Using a Blinded, Staggered-Onset Design Biological Psychiatry, 67 (6), 535-542 DOI: 10.1016/j.biopsych.2009.11.028
The study had a double-blind, placebo-controlled phase: the patients weren't told when the DBS electrodes were going to be switched on. As the graphs show, in the 3 patients who were randomly selected to have them switched on early, 2 responded pretty much immediately, while in the 3 patients whose electrodes were left off, none responded until they were turned on 30 days later, although the response at this point was fairly gradual.Finding the optimal settings for an individual subject proved challenging...unlike other experiences with DBS, there is not a clear positive symptom (e.g., tremor improvement) to gauge settings. In this study... the goal was to select parameters that produced some benefit in mood or anxiety symptoms acutely, with minimal side effects.
Worsening in mood or increased anxiety were typically the first symptoms reported following battery depletion or inadvertent inactivation by metal detectors. Other signs of depression, such as diminished energy or interest, also emerged within days of device interruption... Exacerbation of OCD symptoms generally lagged the emergence of affective or anxiety symptoms.
Goodman, W., Foote, K., Greenberg, B., Ricciuti, N., Bauer, R., Ward, H., Shapira, N., Wu, S., Hill, C., & Rasmussen, S. (2010). Deep Brain Stimulation for Intractable Obsessive Compulsive Disorder: Pilot Study Using a Blinded, Staggered-Onset Design Biological Psychiatry, 67 (6), 535-542 DOI: 10.1016/j.biopsych.2009.11.028
Apparently, many parents are concerned about the possible impact of strong magnetic fields on children, and are unwilling to allow their children to get MRI scanned for research purposes; the article reports on two Chinese neuroscientists who were unable to find healthy children to volunteer for their MRI studies.“I would not dare to allow my children to be tested by MRI,” says radiologist Han Hongbin of Peking University Third Hospital. “Nobody can ensure that there is no potential danger,” such as during nonroutine MRI scans that use extremely powerful magnetic fields, he says.This is not a problem I've heard of amongst Western researchers, but on the other hand, it's not all that bizarre. In Britain, and as far as I know elsewhere too, standard practice is never to include women who are (or might be) pregnant in fMRI studies. This is not because strong magnetic fields have any known risks for unborn babies, or indeed anyone else. It's purely a better-safe-than-sorry precaution. But it sounds as though the concerns of Chinese parents are of that kind as well.
Apparently, many parents are concerned about the possible impact of strong magnetic fields on children, and are unwilling to allow their children to get MRI scanned for research purposes; the article reports on two Chinese neuroscientists who were unable to find healthy children to volunteer for their MRI studies.“I would not dare to allow my children to be tested by MRI,” says radiologist Han Hongbin of Peking University Third Hospital. “Nobody can ensure that there is no potential danger,” such as during nonroutine MRI scans that use extremely powerful magnetic fields, he says.This is not a problem I've heard of amongst Western researchers, but on the other hand, it's not all that bizarre. In Britain, and as far as I know elsewhere too, standard practice is never to include women who are (or might be) pregnant in fMRI studies. This is not because strong magnetic fields have any known risks for unborn babies, or indeed anyone else. It's purely a better-safe-than-sorry precaution. But it sounds as though the concerns of Chinese parents are of that kind as well.
LINK AQUI..
PARA VOCÊ MULHER..VENHA VER...
Meus Mimos-
